General Cell Lines and Cell Cultures
Eurofins Discoverx PrecisION hKv2.1/hKv9.2 Recombinant Stable Cell Line, 2 vials. (CYL3067)
The PrecisION hKv2.1/hKv9.2 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying Kv2.1/Kv9.2 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses Kv2.1/Kv9.2 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Biochain Institute Inc Paraffin Tissue Section - Human Kidney Tumor: Clear cell carcinoma, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx ChemiScreen CB2 Cannabinoid Receptor Membrane Preparation, 1 vial. (HTS020M)
The ChemiScreen CB2 Cannabinoid Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CNR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach or to screen for GPCR activity using GTPγS assays. Increased binding affinities or GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen A1 Adenosine Receptor Membrane Preparation, 1 vial. (HTS047M)
The ChemiScreen A1 Adenosine Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of ADORA1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Cell Applications Inc Rat Dorsal Root Ganglion Neurons Total Kit
Rat Dorsal Root Ganglion Neurons Total Kit:(R8820N-10) Cryopreserved (RDRGN), 1 vial(R823K-100) Rat Neuron Culture Media, 100ml(029-10) Neuron Coating Solution II, 10ml(R823P-10) Neuron Plating Solution, 10ml
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Parathyroid, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PathHunter U2OS SSTR5 β-Arrestin Cell Line, 2 vials. (93-0402C3)
The PathHunter SSTR5 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR5 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged SSTR5 and EA-tagged β-Arrestin-2. Activation of SSTR5 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 OPRL1 Gi Cell Line, 2 vials. (95-0115C2)
The cAMP Hunter OPRL1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orphanin FQ) based activation of OPRL1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type OPRL1, a naturally Gi/Go coupled GPCR. Upon activation of OPRL1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Merck Pneumococcal polysaccharide powder Type 1 (d1) 2mg
Purified pneumococcal polysaccharides are manufactured by Merck & Company for small-quantity distribution by ATCC. The pneumococcal powders include types that are components of the current 23-valent vaccine against Streptococcus pneumoniae. Each of the polysaccharide antigens used in the polyvalent vaccine is extracted and purified separately. These vaccine products can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
Eurofins Discoverx ChemiScreen EP1 Prostanoid Receptor Stable Cell Line, 2 vials. (HTS099C)
The ChemiScreen EP1 Prostanoid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PTGER1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ACROBiosystems HEK293/Human OX40 Ligand / TNFSF4 Stable Cell Line
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
ACROBiosystems HEK293 Membrane-Bound human TL1A Stable Cell Line, 2 vials, 1 mL each, at least 5x10^6 cells per vial, adherent, Puromycin selection, DMEM + 10% FBS
The HEK293/Membrane-Bound human TL1A Stable Cell Line is a genetically engineered cell line optimized for robust TL1A binding assays. This adherent cell line expresses membrane-bound human TL1A after specific amino acid deletion. With comprehensive application data and stringent quality control, this cell line facilitates reliable bioassays supported by validated stability data.
- Cell line optimally designed for TL1A binding assays
- Membrane-bound human TL1A expressed
- Flow cytometry used for expression confirmation
- Adherent growth properties
- Selection marker: Puromycin, 2 μg/mL
- Complete growth medium: DMEM + 10% FBS
- Mycoplasma and sterility tested: negative results
- Comprehensive quality control records available
